ISSN : 2146-3123
E-ISSN : 2146-3131

A Unique Case of Merkel Cell Carcinoma with Ovarian Metastasis
Arbil Açıkalın 1, Aysun Uğuz 1, Derya Gümürdülü 1, Semra Paydaş 2, Ümran Küçükgöz Güleç 3
1Department of Pathology, Çukurova University Faculty of Medicine, Adana, Turkey
2Department of Medical Oncology, Çukurova University Faculty of Medicine, Adana, Turkey
3Department of Gynecology and Obstetrics, Çukurova University Faculty of Medicine, Adana, Turkey
DOI : 10.5152/balkanmedj.2014.14117
Pages : 356-359


Background: Merkel cell carcinoma (MCC) is a rare cutaneous/mucosal malignancy with very aggressive biology and increasing incidence. Ovarian metastasis is an exceptionally rare site for MCC, and only two cases have been reported in the literature.

Case Report: We report MCC with ovarian metastasis. A 34 year-old female with previously excised MCC from preauricular skin presented with a pelvic mass 15 months after first diagnosis. Anti-cytokeratin (CK) 20 positivity, LCA (leucocyte common antigen), and TTF-1 (Thyroid transcription factor-1) negativity confirmed metastatic ovarian MCC. There was no evidence of recurrence or metastasis at 12 months after salpingo-oopherectomy.

Conclusion: MCC should be considered in the differential diagnosis of primary and metastatic undifferentiated small round cell tumors of the ovary.

Keywords : Carcinoma, Merkel cell, metastasis ovarian, neoplasms
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