ISSN : 2146-3123
E-ISSN : 2146-3131

The Importance of Serum Total and Lipid-Bound Sialic Acid as Markers in Patients With Small Cell and Non-Small Cell Lung Carcinoma
Selma Süer Gökmen 1, Cem Kazezoğlu 2, Güldeniz Altıay 2, Erhan Tabakoğlu 3, Özgül Güngör 4, Mevlüt Türe 5
1Trakya Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, Edirne
2Trakya Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Anabilim Dalı, Edirne
3Trakya Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Edirne, Turkey
4Trakya Üniversitesi Tıp Fakültesi 1Biyokimya Anabilim Dalı, Edirne
5Trakya Üniversitesi Tıp Fakültesi Biyoistatistik Anabilim Dalı, Edirne
Pages : 101-108

Abstract

Objectives: Serum total sialic acid (TSA) and lipid-bound sialic acid (LSA) levels were investigated in patients with small and non-small cell lung carcinoma and their role in discriminating small from non-small cell lung carcinoma and lung carcinoma from healthy individuals was evaluated.

Patients and Methods: The study included 159 male patients with non-small cell lung carcinoma (n=102) and small cell lung carcinoma (n=57) who never received chemotherapy and/or radiotherapy and 35 healthy volunteers as controls. Serum TSA and LSA levels were determined by the methods of Warren and Katopodis, respectively.

Results: Serum TSA and LSA levels in both patient groups were significantly elevated when compared with controls (p<0.001), but the patient groups did not differ significantly in this respect. Receiver operating characteristic (ROC) analysis showed that TSA was more specific and LSA was more sensitive in distinguishing patients with non-small cell carcinoma from healthy individuals. On the other hand, LSA was found to be more sensitive in distinguishing patients with small cell carcinoma from healthy controls.

Conclusion: Serum total and lipid-bound sialic acid may play an important role as biochemical markers in distinguishing patients with small and non-small cell lung carcinoma from healthy subjects.

Keywords : Small cell lung cancer; non small cell lung cancer; total sialic acid; lipid-bound sialic acid; marker
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