Mirac Ajredini, Arman Erkan, Amishi Desai, et al.
This study by Ajredini et al. synthesizes contemporary evidence on the transabdominal surgical management of ileal pouch failure, with a focus on standardized preoperative evaluation, unified nomenclature, the Remzi classification for reoperative pouch surgery, and the role of multidisciplinary care in specialized high-volume centers.
Rongxing Qin, Hongyu Xu, Qingchun Qin, et al.
This study by Qin et al. integrates single-cell RNA sequencing, spatial transcriptomics, and molecular docking analyses to delineate cellular heterogeneity and intercellular communication in carotid atherosclerosis, and to identify cannabidiol-related molecular targets with potential therapeutic relevance.
Chongze Lin, Sisi Shao, Qianjia Wu, et al.
In this study, Lin et al. analyzed NHANES 1999–2018 data to evaluate the impact of social determinants of health on all-cause and cardiovascular mortality among U.S. adults with hyperuricemia and/or gout, showing that cumulative social disadvantage is an independent predictor of mortality, particularly in individuals under 60 years of age.
Zehra Manav Yiğit, Aydan Mengübaş Erbaş, Ayberk Türkyılmaz, et al.
This study by Manav Yiğit et al. characterizes the molecular and clinical spectrum of Wiedemann–Steiner syndrome in the largest Turkish cohort to date, identifying nine novel KMT2A variants and highlighting expanded neurodevelopmental, endocrine, and systemic features without significant genotype–phenotype correlations.
Erjie Xie, Yuedi Tang
This study by Xie and Tang investigates whether the severity and longitudinal trajectories of depressive symptoms are associated with the risk of hearing loss among adults aged 55 years and older.
