ISSN : 2146-3123
E-ISSN : 2146-3131

Pityriasis Rosea Associated with Pegylated Interferon Alfa and Ribavirin Treatment in a Patient with Chronic Hepatitis C
Rahmet Güner 1, Şiran Keske 2, İmran Hasanoğlu 3, Mehmet Taşyaran 1
1Department of Infectious Diseases and Clinical Microbiology, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey
2Department of Infectious Diseases and Clinical Microbiology, Polatlı Duatepe State Hospital, Ankara, Turkey
3Department of Infectious Diseases and Clinical Microbiology, Atatürk Education and Research Hospital, Ankara, Turkey
DOI : 10.5152/balkanmedj.2012.109
Pages : 253-254


Background: Pityriasis rosea is an acute inflamatory skin disease that the etiology is unknown but some viral agents like human herpes virus-6 and 7 and drugs are suspected.

Case report: A-58-year-old man with chronic hepatitis C was being followed up in our hospital. Pegylated interferon (PEG-IFN) alfa-2b (100 µg per week) and ribavirin (1000 mg/day) was started. In the third month of this treatment, the patient was diagnosed with pityriasis rosea (PR), which was confirmed by skin biopsy. PEG-IFN alfa-2b treatment for chronic hepatitis C was maintained and no therapy was given for PR. The lesions spontaneously improved within 5 weeks.

Conclusion: Interferon and ribavirin have several cutaneous side effects. Our case is the first case of PR, emerged in a patient with chronic hepatitis C while receiving PEG-IFN alfa 2b and ribavirin.

Keywords : Kronik Hepatit C Tanılı Bir Hastada Pegile Interferon alfa ve Ribavirin Tedavisi ile İlişkili Pitriazis Rosea
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