Jiahan Ke, Xiaohan Qiu, Min Wang, et al.
Ke et al. discovered that febuxostat-mediated urate-lowering medication dramatically improves clinical outcomes in heart failure patients with intact ejection fraction, especially those with increased serum uric acid and BNP levels.
Habibe Tülin Elmaslar Mert, Mehmet Solak, Pelin Sarı Serin, et al.
Mert et al. present a comprehensive systematic review of urogenital cystic echinococcosis, emphasizing its epidemiological patterns, predominant renal involvement, frequent misdiagnosis as neoplasms, and the critical role of radiological imaging supported by ultrasonography and CT in diagnosis, with surgery and antiparasitic therapy serving as the primary treatment.
Derong Huang, Qing Wen, Yuchen Su, et al.
Huang et al. identify the miR-17-5p/BNIP3 axis as a critical regulator of mitochondrial autophagy and fibrotic remodeling in cardiac fibroblasts, implying that it could be a novel therapeutic target for preventing myocardial fibrosis and heart failure progression.
Pan Zhipeng, Kang Lixia, Chen Ling
Zhipeng et al. demonstrate that fat mass and obesity-associated protein-induced m6A demethylation activates the mTORC1 pathway through raptor overexpression, boosting adipogenic differentiation of bone marrow MSCs and promoting chemoresistance in acute myeloid leukemia, implying new therapeutic targets to overcome treatment fail.
Eda Karaismailoğlu, Serkan Karaismailoğlu
Karaismailoğlu et al. observed that tree-based machine learning models, specifically Extra Trees, can accurately predict low bone mineral density from clinical and biochemical data, detecting both known and unknown risk factors for osteoporosis.
